These papers include letters, broadsides, and other documents pertaining to various branches of the Rittenhouse family, in particular, David Rittenhouse and his daughter Elizabeth "Betsey" Rittenhouse Sergeant. Included are references to Benjamin Smith Barton, and copies of documents concerning the Barton family, especially Thomas Barton, in Fanny Abbott's, "Family Records."

David Rittenhouse (1732-1796) was one of the most prominent American men of science of the 18th Century. A skilled instrument maker, Rittenhouse was the an astronomer, playing a major role in recording the 1769 Transit of Venus, among many accomplishments. Rittenhouse also conducted important survey work for the state of Pennsylvania, establishing the state's western border, as well as overseeing the completion of the Mason-Dixon survey. In addition to his scientific endeavors, Rittenhouse's work for American independence places him among the important founding fathers. Subordinating his scientific interests for the greater good of Pennsylvania during the American Revolution, Rittenhouse served as a member of both the Pennsylvania Assembly and the Pennsylvania Constitutional Convention, and held powerful positions on the Pennsylvania Council of Safety and the subsequent Committee on Safety. Rittenhouse also served as the first director of the United States' Mint, at the behest of President George Washington. Rittenhouse was elected to the American Philosophical Society in 1768 and played a major role in placing the Society on the scientific map. He held many positions in the Society, including serving as its President from 1791 until his death in 1796. The Rittenhouse papers span 1774 to 1932, and consist of 61 items, over 0.25 linear feet. The collection is comprised mainly of correspondence, but also includes receipts, genealogies and broadsides.

These papers reflect Isaac Hays' interests and activities in the medical profession and as an editor. His interest in paleontology, especially in the controversy with G. W. Featherstonhaugh, is also represented. There is one separate volume (77 letters) containing correspondence about natural history and naturalists, written to Hays by C. L. Bonaparte, George Ord, Thomas Say, and Charles A. Lesueur. The correspondence in the larger collection, however, contains much material on the American Journal of the Medical Sciences, particularly illuminated in the correspondence with John D. Godman. The I. Minis Hays material consists of letters from doctors, relating to medicine and medical publications and editing, as well as medical organizations. Most significant of the correspondence is that with John Shaw Billings (ca. 60 letters).